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In his autobiography Stories I Only Tell My Friends, he wrote regarding Sheen, "We were both nerds [...] he wanted to be a baseball player." One of Lowe's earliest roles came in the 1983 TV film Thursday's Child, for which he received his first Golden Globe Award nomination for Best Supporting Actor in a Series, Miniseries, or Television Film.His breakthrough role was his big screen debut in 1983, when he and Emilio Estevez were cast in Francis Ford Coppola's The Outsiders. Elmo's Fire, making them the two more prominent actors from the group known as the Brat Pack. followed, with Demi Moore (who had starred alongside Lowe in St. He then received his second Golden Globe Award nomination for Best Supporting Actor for his role as the mentally disabled Rory in Square Dance (1987).In an episode broadcast on May 16, 2010, his character was part of a multi-vehicle crash involving a large truck and was put into a coma, the storyline was wrapped up in the first episode of the fifth season; Lowe did not appear in the episode.In June 2006, he was the guest host for an episode in the third series of The Friday Night Project for the United Kingdom's Channel 4.The year 2004 marked his return to this genre; he had appeared in 1994's The Stand, based on Stephen King's book of the same name.
In 2011, Lowe appeared on The Oprah Winfrey Show and stated that he left the show because he did not feel he was being respected, when the other lead characters received a raise and he did not. In 2005, he starred as Lieutenant Daniel Kaffee in a London West End production of Sorkin's play A Few Good Men, the first time the two had worked together since The West Wing.In addition to his 2001 Emmy nomination for The West Wing, He is of German, English, Irish, Scottish, and Welsh ancestry. , Lowe found out that one of his ancestors, Christopher East, was a Hessian soldier.His ancestor was fighting under the command of Colonel Johann Gottlieb Rall and was captured at the American victory at Trenton, New Jersey, on the morning of December 26, 1776.When the show premiered, Seaborn was considered the lead, and the pilot centered on the character.But the acclaimed cast of the show—including Allison Janney, Richard Schiff, Dulé Hill, John Spencer, Bradley Whitford, Martin Sheen (whose President Bartlet was initially scripted as a small role) and Stockard Channing (whose First Lady was initially scripted as a guest role)— were all strong actors and eventually Lowe's character was no longer the lead.
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After leaving the show, Lowe was the star and executive producer of a failed NBC drama, The Lyon's Den (2003). Although Lowe had expressed unhappiness about his decreased role on that show at the time of his departure, he has now repeatedly said that any animosity between them is over and that he was pleased to be working once more with Sorkin, whose talents as a writer Lowe highly regards. Derek Shepherd of Grey's Anatomy, which eventually went to Patrick Dempsey.