Sedating over the counter updating bifold doors
The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD."In some studies we reviewed, some people actually experienced more sedation with the newer, nonsedating formulas than with the older, sedating products.Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications."We're not saying that there's not a difference," says lead researcher Bruce G.Interactions with other drugs are more common with first-generation antihistamines compared with second-generation antihistamines.Second generation antihistamines were developed in the 1980s and are much less sedating than first-generation antihistamines.Over-the-counter sleep aids can be effective for an occasional sleepless night. Most over-the-counter sleep aids contain antihistamines. Tolerance to the sedative effects of antihistamines can develop quickly — so the longer you take them, the less likely they are to make you sleepy.
"The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.
They act on histamine receptors in the brain and spinal cord and in the rest of the body (called the periphery).
They also act on muscarinic, alpha-adrenergic, and serotonin receptors.
They act on histamine-1 receptors in the periphery and are unlikely to penetrate the brain, so are less likely to cause side effects or interact with drugs.
Most second-generation antihistamines do not cause drowsiness, although some (such as cetirizine and fexofenadine), may be more likely to do so at higher dosages.