Dating someone with sickle cell
This is a reason why so few reference ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits." For more information, please read the article Reference Ranges and What They Mean. Their meaning comes from comparison to reference ranges. Reference ranges are the values expected for a healthy person. By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. With a normal hemoglobin gene copy from one parent and a Hb S gene copy from the other parent (heterozygous), a person is said to have sickle cell trait and to be a sickle cell carrier. When someone has two Hb S gene copies (one from each parent; homozygous), then the person has sickle cell anemia (disease). The affected person can suffer painful episodes and a variety of complications when sickled cells become lodged in and obstruct small blood vessels (vaso-occlusion). Sickle cell tests are done to determine whether someone is producing hemoglobin S and thus carrying a sickle gene. If results of a newborn screen are abnormal, then one or more sickle cell tests may be ordered to confirm abnormal findings.
Hemoglobin is a protein found in red blood cells (RBCs) that binds to oxygen in the lungs and carries it to tissues throughout the body. Values that are outside expected ranges can provide clues to help identify possible conditions or diseases. While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. These can include splenic sequestration (a rapid enlargement of the spleen), damage to organs, tissues, or bones due to a lack of blood flow (such as to the kidneys) or stroke, which occurs in 10% of children affected by sickle cell disease. Tests: Hemoglobinopathy Evaluation (Hemoglobin Electrophoresis; Hemoglobin Isoelectric Focusing; Hemoglobin S Solubility; Hemoglobin Fractionation by HPLC) Complete Blood Count; Blood Smear; Iron Tests Conditions: Sickle Cell Anemia, Anemia, Hemoglobin Abnormalities Screening: Newborns: Congenital and Genetic Disorders American Sickle Cell Anemia Association Sickle Cell Information Center Sickle Cell Disease Association of America National Heart, Lung and Blood Institute Information Center: What is Sickle Cell Anemia?
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